Matthew:
Definitely consider playing with a virtual deck - a) you have access to pretty much whatever cards are legally allowed and you aren't limiting yourself to your own collection, and b) if you have a suitable method of managing your deck/hand/table etc (I recommend my spreadsheet but then I am biased since I developed it!), then you don't need to keep your cards physically accessible during a game.
I recommend LackyCCG, as it is not reliant on Excel, shows you the card images, and more importantly has a really good shuffler.
The only problem is it doesn't analyze decks for legality in a format, which Matt's spreadsheet does.