Star Trek?
Hm. I had a game up a while back -- it was set in Deep Space 4, perched between the Neutral Zone, the Delta Quadrant, and the Typhon Expanse. I think the point in the timeline was right after the end of the Dominion War.
Mechanically, it was the system by Last Unicorn Games (so it was affectionately called 'LUGTrek'). I even took a couple gears from the Dune RPG they made.
My original notes are still here, stuff about the station and what-not. Game mechanics. I'd had a lot of enthusiastic players happily making characters before, but when I officially started the game three-quarters of them stopped responding.
Want me to revive it?