I was thinking of setting a game in the Worm superhero universe using either Worlds in Peril or Masks.  The game would be set before or parallel to the original Worm Story

Almost definitely would be in for that.  But I'd need time to pick up either system.

In reply to Aidhogan (msg # 2):

I'm up for a Worm RP, but I'm not the biggest fan of games Powered By The Apocalypse. The dice engine is great for the creation of drama and tension, but I've found it subpar for task resolution.

Perhaps Mutants & Masterminds 3, Fate CORE/Accelerated (Threads of Fate?), Numenera's Unmasked, or the old TSR Marvel FASERIP system as alternatives?

I'd lean slightly towards Masks over Worlds in Peril, but only slightly.

In reply to wingnut2292 (msg # 3):

I'm actually a fan of PbTA in general so I think I'm going to stick with those options.

Glad to see that there is some interest

Yeah, most of the power sets in the Worms universe would also have to be just massive Variable structures to represent accurately in M&M.  Consider how many different things Skitter learned to use bugs for in just a few months of practice.  I can see Cortex+ pulling it off, but really nothing crunchier than that.  Not with fidelity to the feel of the source material.

I think the main factor in deciding between systems would be if people want a ward game which Masks would be great for or something villainous or focused on more established heroes

I think a Ward game would be more interesting the darker it gets. Learning to betray who you've tried to become to enforce an order only the idealistic past you even cares about? Ouch.

Villain/Rogue games work at lighter tones, I think, counterintuitive though that may be. Hurting people some is a given, which makes conflict take on questions of What Cost, Freedom? in much more direct ways. I expect that to also mean much franker ethical positions. Less ego-horror, probably more body-horror.