IC: Cepheus Engine (2d6 OSR Science Fiction)
As the title indicates, I have been really wanting to run a game using the Cepheus Engine. For those not familiar, the system is drawn from Traveller roots, sort of stripped down a bit and rebuilt to taste.
In any case, what I had in mind was using the Hostile setting, from Zozer Games, which is drawn from early cyberpunk works, and the good parts of the Alien movie franchise, among other things. It makes for a blue collar space, retro-future feel which I find pretty cool and compelling.
If you can imagine playing as the crew of a ship similar to the Nostromo, you have the right idea for what I have in mind.