Need a Large Fleshed Out Published City
Google Judges Guild. Citystate of the Invincible Overlord was always a favorite of mine, back int he day.
There was also a series of "universal" city books (and related compatible source books for encounters, NPCs, etc) that had different sections of the same city published by a company back in the 80s and 90s, but I can't remember which company. What it gave you was relative power levels (knowledge, magic, combat) that you would have to use to convert to the system you wanted.
And, of course, Chaosium converted the Thief's World Series city of Sanctuary into a map with rules and NPCs appended for a variety of game systems. Of course, much like any of the D&D compatible ones above, you might have to do a bit of edition conversion. As I recall, they even had an expansion which had a couple new systems, plus an update for a new edition of one of the older systems in the original boxed set.
In any event, play with google a bit and you're likely to find several options.