I just got done binge watching all four seasons of The Strain. I was curious to the people out in RPOL land, what system you would use if you were creating a game set in that Universe, with Strigoi vampires, The Ancients, the Master, etc. I had a few ideas in mind.

World of Darkness 2.0 Making edits to add in the Master Strigoi, his loyal servants, and the Munchers. Prolly just limit it to one type of vampire clan, just the Nosferatu, just add some of the other powers for Celerity, etc.

Dead Reign, Palladium system, it has the salvaging/Survival feel down perfectly for the setting. The vampires in Dead Reign have a varying degree of activity, From Slouchers that pretend to be dead and then spring on you, to fast Zombie types.

All Flesh Must be Eaten. I know its vampires, and not zombies, but AFMBE is a great quick system that could work.

Any other suggestions, or does anyone know of a fan edit that might be out there.

Night's Black Agents might be a good way to go too, although it would take a bit of work to shift the focus from "ex-spies in Europe" to "random people in New York."  It's based on the Gumshoe system, so if you're familiar with that then you have some idea of the mechanics.  I haven't read or played the game myself, but what I've gathered from listening to Ken Hite's podcast is that it does include lots of options for customizing your vampires and their minions, and also some rules to guide how the vampires' plans progress over the course of the game if the PCs aren't interfering sufficiently (or maybe even if they are?).

If I used World of Darkness then I'd make them Tzimisce. The Munchers would be some of their ungodly creations.

Blood Brothers come to mind, with there hive mind.

The Blood Brothers, were created by Sabbat Tremere and Tzimisce rituals combined, with the Tremere gone the Tzimisce can modify the ritual and create the munchers with the added benefit of the tongue and being able to turn others through parasites.