Even if I hadn't mentioned that the Palladium system in all its clunky, broken glory is part of the experience I'm looking for, I don't like Savage Worlds in general.
Jack Starkiller:
I am interested, but would you care to work toward narrowing down the idea?
If you're interested in running I'd be more than happy to help narrow the options. :) I wanted to keep it open so a potential GM didn't say, "Ah, this person only wants X, but I really want to run a game that does Y."
The only thing I'm not directly interested in is a straight-up military campaign. That said, I'd be okay with a ragtag group that might be working against some baddies and occasionally liaison with another group, but are outside of the chain of command and are working toward their own goals. I'll start by throwing out a couple of ideas to see if there's anything to catch your interest and go from there.
Wormwood or Skraypers. These are two settings that I've always felt were underused, and both have interesting elements. The downside to Wormwood is that most native characters can't go anywhere else without losing their various symbiotes/powers. Skraypers could have pretty much any characters from Rifts Earth or Phase World, as well as breaking out the Heroes Unlimited books.
Minion War. Over the top Megaversal Madness(tm). Once again, built-in options for Earth, Phase World and HU, but since it theoretically spans the entire megaverse, people could be dragged into it from all points. It might also be interesting to go the opposite direction of cosmic power - something like a War Correspondent (from Macross II, but there's probably an equivalent somewhere), maybe some kind of medic type, and one or two beefier characters who find themselves caught up in the mess and are trying to help ordinary people and just stay alive in the face of a cosmic-level onslaught (this could also be a good setup for a Chaos Earth game - XD).
Lone Star Escapees. Allows for a wider variety of character types since PCs could either be illegal Lone Star creations or captured by LS to experiment on instead of being automatically executed like would usually happen in a Coalition prison. The main thing I would be looking for here is to start In Media Res post escape, with the players having picked a common goal. I've found that even in tabletop environments this helps keep prison break style games from stagnating.
These aren't the only ideas I'd potentially be interested in, but they're the ones that came to mind off the top of my head. Hopefully, something there catches your imagination or sparks some ideas of your own.