Traveller?
I've had a MT2e game brewing in the background for a while now. It's just about ready to go and I've been re-enjoying a bit of Mass Effect recently, so I'm in the right frame of mind to dive into a space-game. I was going to launch close to the end of the year, but I can probably bring that forward if there's some clear interest in the scenario now.
It's a rather nonstandard setup in which all characters will be members of the Zhodani military, aboard a massive colonial fleet. The focus will initially be mostly on military operations and exploration. The setting is also unusual in that it will incorporate some fantasy elements, including concepts borrowed from novels (chiefly the works of Raymond E. Feist) and from other games and media. A story/adventure arc has been laid out, within which the characters will have a huge amount of freedom to do what they want in the situations they are presented with, but there are clearly defined start- and end-points to the campaign, which I nevertheless expect to keep a group busy for several years of RPoL play. The tone will be quite dark (mature rated, not adult) and will include survival-game elements as the characters struggle on into the unknown, facing terrifying challenges that are unprecedented in the history of the Zhodani.
I realise it's no casual romp in a free trader, but does that sound like it might be of interest?