(IC) Rome?
I have a home brewed system that should work fine for this era, a combination of basic character attributes complimented by a fairly broad selection skills that can be improved or added to over time.
At this stage I am thinking the game will largely be set in the city itself as this gives players the maximum options for character backgrounds from all over the Republic.
I am considering two time periods, around 500 BC during the end of the first kings and the beginning of the Republic, or later around 270 BC just before the First Punic War.